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研究助理教授

裘文慧

0755-88018048

  • 简历
  • 科研
  • 教学
  • 发表论著

裘文慧于2016年7月获得上海大学环境工程专业博士学位。博士期间获得国家留学基金委支持,在University of California, Los Angeles (UCLA)的David Geffen医学院进行博士联合培养。迄今为止以第一或通讯作者在Environmental Science & Technology等杂志发表SCI学术论文9篇。2015年获得博士国家奖学金,2016年获得上海同济高廷耀基金会“青年博士生杰出人才奖学金”。

 

目前任职

 

南方科技大学环境科学与工程学院,研究助理教授

 

教育背景

 

2013-2016:博士(环境工程),上海大学
2014-2015:博士(环境工程),University of California, Los Angeles(UCLA)
2010-2013:硕士(环境工程),上海大学
2006-2010:学士(环境工程),南昌航空大学

 

工作经历

 

2018.02至今:南方科技大学环境科学与工程学院 研究助理教授

2016.12-2018.02:南方科技大学环境科学与工程学院 科研工程师

 

获奖情况及荣誉

 

2016:上海同济高廷耀基金会“青年博士生杰出人才奖学金”

 

学术兼职(部分)

 

2016-至今:环境领域杂志Chemosphere 和 Environmental Science and Pollution Research的审稿人。

研究领域:
1)环境雌激素在水体中的分布水平及其对鱼类免疫毒性的研究
2)抗抑郁药在水体中的分布水平及其对鱼类免疫毒性的研究
3)抗生素的生态风险评价及其水生毒理学

 

简要介绍:
1)环境雌激素在水体中的分布水平及其对鱼类免疫毒性的研究
环境雌激素(环境内分泌干扰物),广泛分布在河流、湖泊和其它水环境中,并能在水体、沉积物和水生生物中检出。双酚A是一种典型的环境内分泌干扰物,主要用于生产聚碳酸酯、环氧树脂、增塑剂等物质的前体物质。由于其在日常生活中的广泛应用及环境中的普遍存在,BPA将对水生态系统产生很多潜在的不利影响。目前许多研究表明,双酚A具有潜在毒性,尤其对新生儿的发育毒性。因此,在部分国家包括中国,生产婴儿奶瓶及部分婴儿用品的原材料中已经禁用BPA。双酚S(BPS)是一类典型的BPA替代物,可以用来合成聚碳酸酯、环氧树脂、增塑剂等物质的前体物质。因为BPS具有和BPA类似的化学结构,且比BPA更为稳定的化学性质,近年已经被广泛应用在BPA free(不含双酚A)的产品上。然而,国内外目前对BPS的毒性研究却还是近乎空白。因此,迫切要求我们进行对BPS的毒性研究,评价标注BPA free的产品是否是真正的安全放心产品。本研究以红鲤鱼原代巨噬细胞和模式生物斑马鱼为研究对象,开展环境相关水平BPA和BPS对鱼类的免疫细胞和神经内分泌系统的毒性效应和致毒机理研究
2)精神类药物在水体中的分布水平及其对鱼类毒性的研究
近年来,随着社会的快速发展以及人们生活压力的不断增加,精神类药物(抗抑郁药,抗癫痫药和抗焦虑药)的使用越来越普遍。精神类药物因其广泛使用,已成为一种典型的水体污染物。监测其水体浓度是了解其污染程度,并提出有效治理方案的重要前提。并且精神类药物不仅会作用于机体的神经中枢,还会影响机体的内分泌系统,免疫系统,生长发育等多个系统。本研究拟以环境水样为检测对象,广泛检测精神类药物在水体中的分布浓度,以鱼类为研究模型,研究精神类药物对内分泌系统,免疫系统,生长发育等多个系统的影响,探究其潜在的致毒机理、
3)抗生素的生态风险评价及其水生毒理学
以广东省为研究目标,全面评价抗生素的污染水平,结合抗生素的生态毒性效应浓度,评价不同抗生素在环境中的生态风险。同时以本项目检测的环境浓度抗生素污染为研究目标,长期暴露水生动物斑马鱼,评价斑马鱼的生长发育毒性,免疫毒性,以及母子传递毒性等,全面分析抗生素的持久低浓度暴露对水生动物的影响。
 

讲授的本科生课程:

环境科学与工程实验
环境监测实验

[1]  Wenhui Qiu, Lei Hu, Ming Yang*. The toxic effects of bisphenol S showing immunomodulation in fish macrophages. Environmental science & technology. 2018, 52 (2), pp 831–838. (JCR Q1,IF=6.198)
[2]  Ming Yang1*(Supervisor), Wenhui Qiu , Ke-Jian Wang. The In Vitro Immune Modulatory Effect of Bisphenol A on Fish Macrophages via Estrogen Receptor α and Nuclear Factor-κB Signaling, Environmental science & technology. 2015, 49, 1888-1895. (JCR Q1,IF=6.198,与导师共同一作).
[3]  Lei, Z., Xue, Y., Chen, W., Wenhui Qiu, Zhang, Y., Horike, S., & Tang, L. (2018). MOFs‐Based Heterogeneous Catalysts: New Opportunities for Energy‐Related CO2 Conversion. Advanced Energy Materials, 8(32), 1801587 (JCR Q1,IF=21.875).
[4]  Wenhui Qiu, Meijuan Fang, Jingyu Liu, Chunmiao Zheng, Ke-Jian Wang. In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish. Science of The Total Environment, DOI: 10.1016/j.scitotenv.2019.02.154.
[5]  Wenhui Qiu, Ming Zheng, Chunmiao Zheng. Photolysis of enrofloxacin, pefloxacin and sulfaquinoxaline in aqueous solution by UV/H2O2, UV/Fe (II), and UV/H2O2/Fe (II) and the toxicity of the final reaction solutions on zebrafish embryos. Science of The Total Environment, 2019, 651, 1457-1468.
[6]  Wenhui Qiu, Yiqun Tian, Chunmiao Zheng. Occurrence of antibiotics in the main rivers of Shenzhen, China: Association with antibiotic resistance genes and microbial community. Science of the Total Environment 653 (2019) 334–341.
[7]  Wenhui Qiu, Ming Yang, Chunmiao Zheng. Bisphenol S-induced chronic inflammatory stress in liver via peroxisome proliferator-activated receptor γ using fish in vivo and in vitro models. Environmental pollution, 2019, 246, 963-971.
[8]  Wenhui Qiu, Yali Zhao, Ming Yang*Nancy L. Wayne. Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System during Early Development in Zebrafish. Endocrinology. 2015, 157, 636-47.  (JCR Q1,IF=4.71).
[9]  Wenhui Qiu, Minghong Wu, Ming Yang*. Suppressive immunoregulatory effects of three antidepressants via inhibition of the nuclear factor-κB activation assessed using primary macrophages of carp (Cyprinus carpio). Toxicology and Applied Pharmacology, 322 (2017) 1–8. (IF=3.791, JCR Q1)
[10]  Wenhui Qiu, Chunmiao Zheng. The in vivo action of chronic bisphenol F showing potential immune disturbance in juvenile common carp ( Cyprinus carpio ) . Chemosphere, 2018, 205 :506-513. ( IF=4.208)
[11]  Wenhui Qiu, Haiyang Shao, Penghui Lei, Chunmiao Zheng, Cunxin Qiu, Ming Yang, Yi Zheng. Immunotoxicity of bisphenol S and F are similar to that of bisphenol A during zebrafish early development. Chemosphere, 2018, 194, 1-8. ( IF=4.208)
[12]  Wenhui Qiu, Shuai Liu; Feng Yang; Peiyao Dong; Minghung Wong; Chunmiao Zheng. Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Ecotoxicology and Environmental Safety. 2019, Accept.
[13]  Wenhui Qiu, Hongyan Zhan, Jiaqi Hu, Ting Zhang, Hai Xu, Minghung Wong, Bentuo Xu, Chunmiao Zheng. The occurrence, potential toxicity, and toxicity mechanism of bisphenol S, a substitute of bisphenol A: A critical review of recent progress. Ecotoxicology and Environmental Safety, 2019, 173, 192-202.
[14]  Wenhui Qiu, Yang Ming, Minghong Wu*, et al. Oxidative stress and immune disturbance after long-term exposure to bisphenol A in juvenile common carp (Cyprinus carpio). Ecotoxicology and Environmental Safety, 2016, 130: 93-102. (IF:3.743)
[15]  Wenhui Qiu, Jingsi Chen, Yang Ming, Minghong Wu, et al. The potential immune modulatory effect of chronic bisphenol A exposure on gene regulation in male medaka (Oryzias latipes) liver[J]. Ecotoxicology and Environmental Safety, 2016, 130: 146-154. (IF:3.743)
[16]  Wenhui Qiu, Shuai Liu, Ming Yang*. The primary culture of carp (Cyprinus carpio) macrophages and the verification of its phagocytosis activity. In Vitro Cell. Dev. Biol.: Anim. 2015, 1-10.
[17]  Ming Yang1*(Supervisor), Wenhui Qiu1, Minghong Wu. Growth inhibition and coordinated physiological regulation of zebrafish (Danio rerio) embryos upon sublethal exposure to antidepressant amitriptyline. Aquat. Toxicol. 2014, 151, 68-76 (JCR Q1, IF=4.129,与导师共同一作).
[18]  Feng Yang, Wenhui Qiu*, Chunmiao Zheng. (2018). Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere, 213, 559-567.
[19]  Jianguo Sheng, Wenhui Qiu*. Monitoring of heavy metal levels in main rivers and residents’ blood of Zhenjiang city, China and Assessment of human elimination via urine and sweat. Environmental Science and Pollution Research. DOI: 10.1007/s11356-016-6287-z. 2016 (通讯作者, IF:2.741)
[20]  Wenhui Qiu, Ming Yang, Nancy L. Wayne. BPS, a popular substitute for BPA, may not be safer. The conversation. 2016.
[21]  Zhen-Dong Lei, Yuan-Cheng Xue, Wen-Qian Chen, Lin Li, Wen-Hui Qiu, Yong Zhang, and Liang Tang. The Influence of Carbon Nitride Nanosheets Doping on the Crystalline Formation of MIL-88B(Fe) and the Photocatalytic Activities. Small, 1802045.
[22]  Ming Yang, Wenhui Qiu, Yang Shen, Minghong Wu. Detection of Rotaviruses in River Water and Sewage Water in Shanghai by RT-PCR. IEEE.
[23]  Hai Xu, Ming Yang, Wenhui Qiu, Chenyuan Pan, Minghong Wu. The impact of endocrine-disrupting chemicals on oxidative stress and innate immune response in zebrafish embryos. Environ. Toxicol. Chem. 2013, 5, 1793-1799.
[24]  Minghong Wu, Hai Xu, Yang Shen, Wenhui Qiu, Ming Yang*. Oxidative stress in zebrafish embryos induced by short-term exposure ;to bisphenol A, nonylphenol, and their mixture. Environ. Toxicol. Chem. 2011, 30(10): 2335-2341.